An Innovative Approach to Mood Enhancement | Home | About IME-12 | FAQs | Reviews | Clinical Data | The Anterior Cingulate is considered the brain’s gear shifter.  Functions associated with this area of the brain include: Cooperation, cognitive flexibility, switching from one idea to another and going with the flow. Hyperactivity in this area is associated with: Worry, obsession, compulsivity, addiction, inflexibility etc. The most common conditions linked to hyperactivity in this area are: OCD, PMS, PTSD, ODD, AD, chronic pain and eating disorders. Baseline Study, before IME-12 During Supplementation with IME-12 SPECT brain scans following supplementation with IME-12 show a down regulation of activity in the anterior cingulate. The Basal Ganglia is associated with motivation, pleasure, anxiety, vigilance and smooth muscle movement. Under-activity in this area is associated with ADD and decreased motivation. Baseline Study, before IME-12 During Supplementation with IME-12 SPECT brain scans following supplementation with IME-12 show increased activity in the Basal Ganglia. Possible side-effects of IME-12 may include hypervigilance and excessive motivation. Higher dosages of IME-12 may produce irritability, tension, anxiety, panic and conflict avoidance. The Deep Thalamus is associated with appetite, motivation, sleep cycles, libido, bonding, body temperature, and flight or fight response. Baseline Study, before IME-12 During Supplementation with IME-12 SPECT brain scans following supplementation with IME-12 show decreased activity in the Deep Thalamus/Limbic. Hyperactivity in this area is associated with decreased motivation, low energy, low self esteem, loss of libido, irritability, negativity, guilt, blame, anger, sleep disorders, loss of appetite, social isolation and inward directed sadness. Results of SPECT Scans of a Healthy Brain, Before and After IME-12 Supplementation.